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Senior Research Associate

San Diego, CA
• Primarily be responsible for developing and performing binding assays, kinetic profiling assays, competition assays, efficacy assays and epitope binning of early therapeutic candidates using a wide range of biophysical and biochemical methods including Biacore, MASS-1, Octet, FRET, ELISA, etc.
• Expected to take part in bioanalytical characterization of early drug candidates using HPLC based methods (SEC, IEC, RP), thermal stability (DSC) and capillary electrophoresis based methods (cIEF, CE-SDS-PAGE).
• Implement and validate protocols.
• Reviewing literature for technical support.
• Data analysis.
• With assistance, executes experiments, conducts analysis and reports results.
• Work with minimal direction to complete assigned tasks.
• Consults colleagues for advice on issues.
• Recognize unexpected outcome/problems; communicates and works with supervisor to solve.
• Learn from the past experience to improve the current process.
• Communicates with peers and supervisors.
• Begin to communicate with departments and customers.
• Works in context of immediate work group or team.
• Has a direct impact on workgroup performance.
• Impact is achieved by contributing to workgroup.
• Bachelor’s or Master’s degree in Biochemistry or related discipline with 2 years of hands on experience in industry focusing on Biologics.
• At least 2 years of industry experience in bioanalytical and biophysical characterization of monoclonal antibodies, Fc-fusion proteins, peptides and antibody-drug conjugates (ADCs).
• Knowledge of protein expression and purification using CHO and HEK293 cells specifically for biologics is a plus.
• Proven track record of developing binding assays for monoclonal antibodies and other forms of biologics candidates using all or any of the following techniques: Biacore, MASS-1, Octet, HTRF, AlphaScreen, ELISA.
• Experience with Lights scattering methods (Wyatts DLS, SEC-MALS) .
• Thermal stability determination using DSC, DSF and formulation screen to identify ideal storage buffer condition .
• Experience in cIEF (by Protein Simple), CE-SDS PAGE is a plus.
• Antibody conjugation experience is a plus.
• Experince in protein expression and purification is a plus.
• Mass spectrometry: Intact mass determination of antibodies and Fc-fusion protein can be an added advantage.
• Excellent written and oral communication skills including ability to present scientific data in group setting.
• Excellent organization to multi-task and manage multiple projects.
• Ability to adapt to rapid changes in projects priorities and meet aggressive timelines
• Committed to working in a collaborative manner across functional areas within matrix organization
• Have mastery of basic lab skills.
• Familiarity with data retrieval and input from database.
• Familiarity with work and business practices to be able to identify and troubleshoot routine problems.
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